Apotheke

Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes,[14][15][16][17] particularly in people who are overweight.[15] It is also used in the treatment of polycystic ovary syndrome,[16] and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication.[18] It has been shown to inhibit inflammation,[19][20] and is not associated with weight gain.[21] Metformin is taken by mouth.[16]

Metformin is generally well tolerated.[22] Common adverse effects include diarrhea, nausea, and abdominal pain.[16] It has a small risk of causing low blood sugar.[16] High blood lactic acid level (acidosis) is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems.[23][24]

Metformin is a biguanide anti-hyperglycemic agent.[16] It works by decreasing glucose production in the liver, increasing the insulin sensitivity of body tissues,[16] and increasing GDF15 secretion, which reduces appetite and caloric intake.[25][26][27][28]